/*!
    Desenvolvido por Rhuan Carlos
    https://rhuan.dev

    BioSupre
 */

@font-face {
  font-family: ProximaNova;
  font-weight: 400;
  font-style: normal;
  src: url(../../../assets/fonts/proxima/proximanova-regular-webfont.eot);
  src: url(../../../assets/fonts/proxima/proximanova-regular-webfont.eot?#iefix) format("embedded-opentype"),url(../../../assets/fonts/proxima/proximanova-regular-webfont.woff) format("woff"),url(../../../assets/fonts/proxima/proximanova-regular-webfont.ttf) format("truetype"),url(../../../assets/fonts/proxima/proximanova-regular-webfont.svg#ProximaNova) format("svg");
}

html {
  font-family: sans-serif;
  font-size: 62.5%;
  -webkit-font-smoothing: antialiased;
  -moz-font-smoothing: antialiased;
  font-smoothing: antialiased;
  text-rendering: optimizeLegibility;
  -webkit-text-size-adjust: 100%;
}

* {
  box-sizing: border-box;
  margin: 0;
  padding: 0;
  outline: none;
}

a {
  text-decoration: none;
}

p {
  margin: 0 0 20px;
}

button,input {
  font-family: inherit;
  font-size: inherit;
  line-height: inherit;
}

body,html {
  position: relative;
  overflow-x: hidden;
}

body {
  font-size: 16px;
  font-size: 1.6rem;
  font-family: Open Sans,arial,sans-serif;
  font-weight: 400;
  color: #333;
}

body,img {
  max-width: 100%;
}

img {
  display: inline-block;
  vertical-align: top;
}

a {
  transition: color .4s ease,background .4s ease,border .4s ease,opacity .4s ease;
  color: #c4170c;
}

a:hover {
  color: ligthen(#c4170c,10%);
}

.container {
  display: block;
  max-width: 480px;
  padding-right: 15px;
  padding-left: 15px;
}

.container,.layout {
  margin-right: auto;
  margin-left: auto;
}

.layout {
  max-width: 1040px;
}

.main {
  padding: 30px 0;
}

.related {
  padding-bottom: 40px;
  background: #f3f3f3;
}

.related__heading {
  font-size: calc(22px + 2 * ((100vw - 420px) / 860));
  font-weight: 400;
  margin-bottom: 20px;
  padding: 15px 0;
  border-top: 2px solid #333;
}

.related__heading,.related__item {
  max-width: 680px;
  margin-right: auto;
  margin-left: auto;
  border-bottom: 1px solid #ccc;
}

.related__item {
  margin-bottom: 30px;
  padding-bottom: 30px;
}

.related__item.-last {
  margin-bottom: 0;
  border-bottom: none;
}

.related__action {
  max-width: 680px;
  margin-right: auto;
  margin-left: auto;
}

.article__header {
  margin-bottom: 30px;
}

.article__title {
  letter-spacing: -.035em;
  font-size: calc(24px + 23 * ((100vw - 420px) / 860));
  line-height: 1.28;
  max-width: 940px;
}

.article__title,.article__title-mini {
  text-align: center;
  margin-left: auto;
  margin-right: auto;
}

.article__title-mini {
  font-size: calc(16px + 4 * ((100vw - 420px) / 860));
  font-weight: 400;
  max-width: 830px;
  margin-top: 15px;
}

.article__title-mini p:last-child,.article__title-mini p:last-of-type {
  margin-bottom: 0;
}

.article__author {
  line-height: 1.67;
  max-width: 890px;
  margin-top: 20px;
  margin-right: auto;
  margin-left: auto;
  padding-bottom: 30px;
  color: #555;
  border-bottom: 1px solid #ccc;
}

.article__author-name {
  font-size: calc(15px + 1 * ((100vw - 420px) / 860));
  font-weight: 700;
}

.article__author-date {
  font-size: 12px;
  font-size: 1.2rem;
}

.button {
  border-radius: 3px;
  -webkit-box-shadow: inset 0 -2px 0 0 rgba(0,0,0,.2);
  font-size: 14px;
  font-size: 1.4rem;
  font-family: Arial,sans-serif;
  font-weight: 700;
  display: flex;
  align-items: center;
  justify-content: center;
  padding: 17px 15px;
  text-align: center;
  text-transform: uppercase;
  color: #fff;
  background: #c4170c;
}

.button:hover {
  background-color: #f12012;
}

.entry {
  font-size: calc(15px + 5 * ((100vw - 420px) / 860));
  line-height: 1.6;
}

.entry h1,.entry h2,.entry h3,.entry h4,.entry h5,.entry h6 {
  letter-spacing: -.035em;
  line-height: 1.28;
  max-width: 680px;
  margin-right: auto;
  margin-bottom: 15px;
  margin-left: auto;
}

.entry h1 {
  font-size: 2em;
}

.entry h2 {
  font-size: 1.8em;
}

.entry h3 {
  font-size: 1.6em;
}

.entry h4 {
  font-size: 1.4em;
}

.entry h5 {
  font-size: 1.2em;
}

.entry h6 {
  font-size: 1em;
}

.entry a {
  text-decoration: underline;
}

.entry>p,.entry>ul {
  max-width: 680px;
  margin-right: auto;
  margin-left: auto;
}

.entry>ul li {
  margin-left: 20px;
}

.footer {
  padding: 30px 0 20px;
  color: #fff;
  background: #c4170c;
}

.footer__columns {
  display: flex;
  flex-wrap: wrap;
}

.footer__logo {
  margin-bottom: 15px;
}

.footer__logo a {
  font-size: 14px;
  font-size: 1.4rem;
  display: inline-flex;
  flex-flow: column;
  color: #fff;
}

.footer__logo a img {
  display: block;
  max-width: 38px;
  margin-bottom: 10px;
  flex: 0 0 auto;
}

.footer__copyright,.footer__links {
  font-size: 12px;
  font-size: 1.2rem;
}

.footer__links,.footer__links li {
  display: none;
}

.footer__links li a {
  color: #fff;
}

.footer__links li a:hover {
  text-decoration: underline;
}

.footer__links li.visible-mob {
  display: inline-block;
}

.header-g1 {
  position: relative;
  display: flex;
  height: 50px;
  background: #c4170c;
}

.header-g1__container {
  position: relative;
  width: 100%;
  text-align: center;
}

.header-g1__container,.header-g1__hamburger {
  display: flex;
  align-items: center;
  justify-content: center;
}

.header-g1__hamburger {
  position: absolute;
  z-index: 1;
  top: 0;
  left: -10px;
  padding: 18px 25px;
}

.header-g1__hamburger a {
  display: flex;
  align-items: center;
}

.header-g1__hamburger .box span {
  display: block;
  flex: 0 0 20px;
  width: 20px;
  height: 2px;
  margin-bottom: 4px;
  background: #fff;
}

.header-g1__hamburger .box span:last-child,.header-g1__hamburger .box span:last-of-type {
  margin-bottom: 0;
}

.header-g1__hamburger .label {
  display: none;
}

.header-g1__hamburger .separator {
  position: relative;
  display: none;
  width: 1px;
  height: 19px;
  margin-right: 25px;
  margin-left: 25px;
  background: url(../../../assets/images/dots.svg);
}

.header-g1__hamburger .logo {
  position: relative;
  top: 2px;
  display: none;
  flex: 0 0 26px;
  max-width: 26px;
  margin-left: 15px;
  color: #fff;
}

.header-g1__logo {
  font-weight: 400;
  font-family: ProximaNova,arial,sans-serif;
  font-size: 24px;
  font-size: 2.4rem;
  position: relative;
  display: block;
  color: #fff;
}

.header-g1__logo a {
  display: inline-block;
  vertical-align: top;
  color: #fff;
}

.header-g1__logo a:hover {
  color: hsla(0,0%,100%,.6);
}

.header-g1__search-button {
  position: absolute;
  z-index: 1;
  top: 0;
  right: -10px;
  display: block;
  align-items: center;
  justify-content: center;
  padding: 17px 25px 11px;
}

.header-g1__search-form {
  display: none;
}

.related-item {
  display: flex;
  flex-flow: column;
  color: #474747;
}

.related-item__image {
  flex: 0 0 auto;
  margin-bottom: 15px;
}

.related-item__image img {
  width: 100%;
}

.related-item__infos {
  flex: 1;
}

.related-item__title {
  font-size: calc(20px + 2 * ((100vw - 420px) / 860));
  line-height: 1.23;
  margin-bottom: 10px;
  color: #c4170c;
}

.related-item__title a:hover {
  color: #373737;
}

.related-item__entry {
  font-size: calc(14px + 1 * ((100vw - 420px) / 860));
  line-height: 1.4;
  margin-bottom: 10px;
}

.related-item__entry p:last-child,.related-item__entry p:last-of-type {
  margin-bottom: 0;
}

.related-item__by {
  font-size: 12px;
  font-size: 1.2rem;
}

.aligncenter,div.aligncenter {
  display: block;
  margin: 5px auto 20px;
  text-align: center;
}

.alignright {
  float: right;
  margin: 5px 0 20px 20px;
}

.alignleft {
  float: left;
  margin: 5px 20px 20px 0;
}

a img.alignright {
  float: right;
  margin: 5px 0 30px 20px;
}

a img.alignleft {
  margin: 5px 20px 30px 0;
}

a img.alignleft {
  float: left;
}

a img.aligncenter {
  display: block;
  margin-right: auto;
  margin-bottom: 30px;
  margin-left: auto;
}

.large-paragraph {
  max-width: 850px!important;
}

.large-paragraph .alignleft,.large-paragraph .alignright {
  float: none;
  text-align: center;
  max-width: 80%;
  height: auto;
  margin-left: auto;
  margin-right: auto;
  display: block;
}

.extrabold {
  font-weight: 800;
}

.regular {
  font-weight: 400;
}

@media (min-width:600px) {
  .header-g1__hamburger {
    padding: 15px 25px 13px;
  }

  .header-g1__hamburger .logo {
    display: block;
  }
}

@media (min-width:768px) {
  .container {
    max-width: 720px;
  }

  .footer__copyright {
    font-size: 11px;
    font-size: 1.1rem;
    padding-right: 0;
  }

  .footer__links li {
    margin-right: 10px;
    padding-right: 10px;
    border-right: 1px solid hsla(0,0%,100%,.2);
  }

  .header-g1__logo {
    max-width: none;
  }

  .related-item {
    flex-flow: row;
  }

  .related-item__image {
    margin-right: 15px;
    margin-bottom: 0;
  }

  .large-paragraph .alignleft {
    float: left;
    max-width: 50%;
  }

  .large-paragraph .alignright {
    float: right;
    max-width: 50%;
  }
}

@media (min-width:992px) {
  body {
    font-size: 18px;
    font-size: 1.8rem;
  }

  .container {
    max-width: 990px;
  }

  .main {
    padding: 50px 0;
  }

  .related {
    padding-bottom: 60px;
  }

  .related__heading {
    margin-bottom: 35px;
    padding: 20px 0;
  }

  .related__item {
    padding-bottom: 40px;
  }

  .article__header,  .related__item {
    margin-bottom: 40px;
  }

  .article__author {
    margin-top: 25px;
    padding-bottom: 35px;
  }

  .entry h1,  .entry h2,  .entry h3,  .entry h4,  .entry h5,  .entry h6 {
    margin-bottom: 20px;
  }

  .footer__columns {
    justify-content: space-between;
  }

  .footer__logo {
    margin-bottom: 25px;
  }

  .footer__logo a {
    flex-flow: row;
    white-space: nowrap;
  }

  .footer__logo a img {
    margin-right: 20px;
    margin-bottom: 0;
  }

  .footer__links {
    display: flex;
    text-align: right;
  }

  .footer__links li:last-child,  .footer__links li:last-of-type {
    margin-right: 0;
    padding-right: 0;
    border-right: none;
  }

  .header-g1 {
    justify-content: center;
    height: 75px;
  }

  .header-g1__hamburger {
    display: flex;
    align-items: center;
    padding-top: 25.5px;
    padding-bottom: 25.5px;
  }

  .header-g1__hamburger .label {
    font-size: 14px;
    font-size: 1.4rem;
    font-family: Open Sans,arial,sans-serif;
    font-weight: 600;
    display: flex;
    align-items: center;
    margin-left: 4px;
    color: #fff;
  }

  .header-g1__hamburger .separator {
    display: block;
  }

  .header-g1__hamburger .logo {
    flex: 0 0 32px;
    max-width: 32px;
    margin-left: 0;
  }

  .header-g1__logo {
    font-size: 32px;
    font-size: 3.2rem;
  }

  .header-g1__search-button {
    display: none;
  }

  .header-g1__search-form {
    position: absolute;
    top: 20px;
    right: 15px;
    display: block;
  }

  .header-g1__search-form input {
    border-radius: 3px;
    font-size: 14px;
    font-size: 1.4rem;
    font-family: Open Sans,arial,sans-serif;
    font-weight: 600;
    transition: all .4s ease;
    width: 165px;
    height: 32px;
    padding-right: 10px;
    padding-left: 30px;
    text-transform: uppercase;
    color: #fff;
    border: none;
    background-color: rgba(0,0,0,.15);
    background-image: url(../../../assets/images/search.png);
    background-repeat: no-repeat;
    background-position: left 10px center;
  }

  .header-g1__search-form input::-moz-placeholder {
    opacity: 1;
  }

  .header-g1__search-form input:-ms-input-placeholder {
    color: #fff;
  }

  .header-g1__search-form input::-webkit-input-placeholder {
    color: #fff;
  }

  .header-g1__search-form input:focus {
    width: 255px;
    color: #686868;
    background-color: #fff;
    background-image: url(../../../assets/images/search-focus.png);
  }

  .header-g1__search-form input:focus::-moz-placeholder {
    opacity: 1;
  }

  .header-g1__search-form input:focus:-ms-input-placeholder {
    color: #686868;
  }

  .header-g1__search-form input:focus::-webkit-input-placeholder {
    color: #686868;
  }

  .large-paragraph .alignleft,  .large-paragraph .alignright {
    max-width: 100%;
  }
}

@media (min-width:1200px) {
  .container {
    max-width: 1130px;
  }

  .main {
    padding: 70px 0;
  }

  .related {
    padding-bottom: 80px;
  }

  .entry>p,  .entry>ul {
    margin-bottom: 30px;
  }

  .footer__links li {
    display: inline-block;
    margin-right: 10px;
  }

  .aligncenter,  .alignright,  div.aligncenter {
    margin-bottom: 30px;
  }

  .alignleft,  a img.aligncenter,  a img.alignleft,  a img.alignright {
    margin-bottom: 40px;
  }
}

@media screen and (min-width:1280px) {
  .related__heading {
    font-size: 24px;
  }

  .article__title {
    font-size: 47px;
  }

  .article__title-mini {
    font-size: 20px;
  }

  .article__author-name {
    font-size: 16px;
  }

  .entry {
    font-size: 20px;
  }

  .related-item__title {
    font-size: 22px;
  }

  .related-item__entry {
    font-size: 15px;
  }
}

@media screen and (max-width:420px) {
  .related__heading {
    font-size: 22px;
  }

  .article__title {
    font-size: 24px;
  }

  .article__title-mini {
    font-size: 16px;
  }

  .article__author-name {
    font-size: 15px;
  }

  .entry {
    font-size: 15px;
  }

  .related-item__title {
    font-size: 20px;
  }

  .related-item__entry {
    font-size: 14px;
  }
}